Wogonoside induces apoptosis in human non-small cell lung cancer A549 cells by promoting mitochondria dysfunction.

Min Luo,Juanmei Mo,Qitao Yu,Shaozhang Zhou,Ruiling Ning, Yu Zhang,Cuiyun Su, Hongzhi Wang,Jiandong Cui

Biomedicine & Pharmacotherapy（2018）

引用 16|浏览6

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摘要

•Wogonoside reduces cell viability and induces cell cycle arrest in A549 cells.•Wogonoside induces apoptosis in A549 cells.•Wogonoside inhibits the growth of A549 cell xenografts in vivo.•Wogonoside induces mitochondria dysfunction in A549 cells.•Wogonoside regulates AMPK/mTOR signaling in A549 cells.

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关键词

Wogonoside,Non-small cell lung cancer,Viability,Apoptosis,Mitochondria,AMPK/mTOR signaling

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