Severe Allograft Rejection In An Intestinal Transplant Patient Following Oral Immunoglobulin Treatment For Chronic Norovirus Infection: A Case Report

In an intestinal transplant patient under triple immunosuppression therapy with tacrolimus levels > 10 ng/L, a 2-day oral immunoglobulin therapy given as treatment for chronic norovirus infection was temporally closely associated with the development of severe steroid-resistant acute graft rejection, thus suggesting that oral immunoglobulin might be able to promote a rejection response.