Quantitative Intensity Harmonization of Dopamine Transporter SPECT Images Using Gamma Mixture Models.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging（2019）
Abstract
The GCDF normalization method is useful to standardize the intensity of DAT SPECT images in an automated fashion and enables the development of unbiased algorithms using multicenter datasets. This method may constitute a key pre-processing step in the analysis of this type of images.
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Key words
SPECT,Dopamine transporter,Intensity normalization,PPMI,Gamma distribution,Multicenter studies
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