Dual-Organ Transplantation In Older Recipients: Outcomes After Heart-Kidney Transplant Versus Isolated Heart Transplant In Patients Aged 65 Years

OBJECTIVES Combined heart-kidney transplantation has successful outcomes. With an increasing number of patients with end-stage heart disease, there is a high incidence of significant renal insufficiency that may necessitate combined heart-kidney transplant. Outcomes for heart-kidney transplant recipients aged 65 years are not well described.METHODS Between 2010 and 2015, 163 recipients 65years of age were transplanted in a single centre: 12 heart-kidney and 151 isolated heart transplants. Outcomes assessed were estimated glomerular filtration rate at 1, 6 and 12months after transplant, the need for dialysis, 1-year survival, 1-year freedom from rejection, 1-year freedom from cardiac allograft vasculopathy and 1-year freedom from non-fatal major adverse cardiac events.RESULTS Recipient ages were 67.81.6 and 69.0 +/- 2.8years for heart-kidney transplant and isolated heart transplant, and pretransplant estimated glomerular filtration rates were 26.6 +/- 9.4 vs 55.2 +/- 18.9, respectively. At 1 month (66.3 +/- 31.4 vs 67.2 +/- 28.0, P=0.92), 6 months (68.1 +/- 21.3 vs 60.5 +/- 19.6, P=0.20) and 12 months (58.6 +/- 21.5 vs 52.4 +/- 18.5, P=0.27) post-transplant, estimated glomerular filtration rate was similar for heart-kidney transplant versus isolated heart transplant. There was a trend towards reduced 1-year freedom from temporary dialysis after heart-kidney transplant relative to isolated heart transplant (75.0% vs 90.4%, P=0.06) without a difference in 1-year freedom from chronic dialysis (100% vs 95.2%, P=0.46). There were no differences in 1-year survival, 1-year freedom from any treated rejection, acute cellular rejection, antibody-mediated rejection, cardiac allograft vasculopathy and non-fatal major adverse cardiac events.CONCLUSIONS For patients 65 years old, heart-kidney transplant can achieve outcomes on par with heart transplant alone.