尼妥珠单抗联合化疗二线及以上治疗晚期肺鳞癌
Zhongguo fei ai za zhi = Chinese journal of lung cancer(2016)
Abstract
背景与目的表皮生长因子受体(epidermal growth factor receptor, EGFR)过表达在肺鳞癌中常见,而与预后差相关。本研究旨在观察抗EGFR单克隆抗体尼妥珠单抗联合化疗二线及以上治疗晚期肺鳞癌的疗效及安全性。方法回顾性分析13例尼妥珠单抗联合化疗二线及以上治疗的晚期肺鳞癌患者的临床资料,分别采用实体瘤疗效评价标准1.1版和美国国立癌症研究所通用毒性标准4.0版进行疗效和安全性评估。结果13例晚期肺鳞癌患者中,1例完全缓解(complete response, CR),2例部分缓解(partial response, PR),4例稳定(stable disease, SD)和6例进展(progressive disease, PD),总有效率(overall response rate, ORR)为23.1%,临床获益率(clinical beneift rate, CBR)为53.8%。6例患者进行了EGFR免疫组化检测,5例EGFR 3+,1例EGFR 2+,这6例患者1例CR,1例PR,4例SD,ORR为33.3%,CBR为100.0%。23.1%的患者出现3度-4度血液学毒性,非血液学毒性轻微,2例(15.4%)出现尼妥珠单抗相关皮疹。结论尼妥珠单抗联合化疗二线及以上治疗晚期肺鳞癌有效且不良反应容易耐受,尤其是EGFR表达阳性的患者。
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Key words
Lung neoplasms,Nimotuzumab,Combined therapy
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