Prevalence and outcomes of uncommon BCR-ABL1 fusion transcripts in patients with chronic myeloid leukaemia: data from a single centre.
BRITISH JOURNAL OF HAEMATOLOGY(2018)
Abstract
To explore the type, prevalence and outcomes in chronic myeloid leukaemia (CML) patients with uncommon BCR-ABL1 transcripts in the era of tyrosine kinase inhibitors (TKIs), uncommon BCR-ABL1 transcripts were screened in 4750 patients by multiplex polymerase chain reaction (PCR), and type-specific real-time quantitative PCR was regularly performed for molecular monitoring. A total of 19 uncommon transcripts, including e1a2, e1a3, e6a2, e8a2, e12a2, unusual e13a2, e13a3, unusual e14a2, e14a3 and e19a2 were identified in 83 (1 7%) patients. The three most frequent types were e19a2, e13a3/e14a3 and e1a2. Compared with the 571 newly diagnosed CML patients in chronic phase with common e13a2/e14a2 transcripts receiving frontline imatinib therapy, patients with the e19a2 (n=16) and e1a2 (n=11) transcripts had significantly reduced probabilities of 1-year complete cytogenetic response (CCyR, P=0 0004 and 0 016) and major molecular response (MMR, P=0 0018 and 0 0035), and patients with the e13a3/e14a3 transcript (n=10) had significantly increased probabilities of 1-year CCyR (P=0 0072) and MMR (P=0 0073). Patients with the e19a2 transcript had low probabilities of 2-year event-free survival (EFS, P=0 0004) and progression-free survival (P=0 0067), and patients with the e1a2 transcript had low probability of 2-year EFS (P<0 0001). Therefore, uncommon BCR-ABL1 fusion transcripts are rare and diverse in patients with CML and may be relevant for TKI therapy outcomes.
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Key words
chronic myeloid leukaemia,uncommon BCR-ABL1 transcripts,tyrosine kinase inhibitors,cytogenetic and molecular response,outcome
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