Sleep spindles in bipolar disorder - a comparison to healthy control subjects.
Acta psychiatrica Scandinavica(2018)
Abstract
A reduction in fast spindle density during N2 sleep points towards thalamic dysfunction as a potential neurobiological mechanism of relevance in bipolar disorder. In addition, a reduced sleep spindle density could be interpreted as a common endophenotype shared with schizophrenia but not unipolar depression and may - if replicated - be of utility in early recognition and risk stratification.
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Key words
biomarker,bipolar disorder,circadian rhythms,sleep,sleep spindles
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