Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry.
CHEMICAL COMMUNICATIONS(2018)
Abstract
Understanding of amyloid aggregation in terms of thermodynamics and kinetics is still limited. We herein examined the mechanism of 2-microglobulin amyloidogenesis using our unique method of isothermal titration calorimetry-based thermodynamic/kinetic measurements, and revealed the energy landscape of polymorphic amyloidogenesis under biological environment-mimicking conditions including shear forces and crowding effects.
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Key words
Isothermal Titration Calorimetry,Thermal Analysis,Macromolecular Crowding
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