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Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry.

Misaki Kinoshita,Yuxi Lin,Itoh Dai,Masaki Okumura,Natalia Markova,John E Ladbury,Fabio Sterpone,Young-Ho Lee

CHEMICAL COMMUNICATIONS（2018）

Cited 13|Views9
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Abstract
Understanding of amyloid aggregation in terms of thermodynamics and kinetics is still limited. We herein examined the mechanism of 2-microglobulin amyloidogenesis using our unique method of isothermal titration calorimetry-based thermodynamic/kinetic measurements, and revealed the energy landscape of polymorphic amyloidogenesis under biological environment-mimicking conditions including shear forces and crowding effects.
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Key words
Isothermal Titration Calorimetry,Thermal Analysis,Macromolecular Crowding
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