A rapid and sensitive chiral LC-MS/MS method for the determination of ketamine and norketamine in mouse plasma, brain and cerebrospinal fluid applicable to the stereoselective pharmacokinetic study of ketamine.
Journal of Pharmaceutical and Biomedical Analysis（2018）
Abstract
•A chiral LC–MS/MS assay for ketamine and norketamine was developed and validated.•Analytical run time was just 5min per injection.•High sensitivity allowed sequential blood collection from an individual mouse.•This method successfully revealed stereoselective profiles in mouse plasma and CNS.•This method would be useful for studying antidepressant actions of ketamine.
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Key words
Ketamine,Norketamine,Chiral LC–MS/MS,Pharmacokinetics,Mice,Antidepressant
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