Visceral adiposity index as an indicator of cardiometabolic risk in patients treated for craniopharyngioma
Endocrine(2016)
Abstract
Purpose Craniopharyngioma is associated with metabolic alterations leading to increased cardiovascular mortality. Recently, the visceral adiposity index has been proposed as a marker of visceral adipose tissue dysfunction and of the related cardiometabolic risk. The role of the visceral adiposity index has never been explored in craniopharyngioma patients. We assessed the cardiometabolic risk on the basis of the visceral adiposity index in craniopharyngioma patients. Methods We evaluated data of 24 patients treated for craniopharyngioma in a single-centre. We investigated the relationship among patients’ clinical and biochemical features, cardiovascular risk -assessed by the Framingham and the atherosclerotic cardiovascular disease risk scores-, visceral adiposity index and adipose tissue dysfunction severity. Results Increased visceral adiposity index was found in 8 patients (33%). Adipose tissue dysfunction resulted to be severe, moderate or mild in 5, 2 and 1 cases. Increased visceral adiposity index significantly correlated with the occurrence of metabolic syndrome ( p 0.027), IRI ( p 0.001), triglycerides ( p < 0.001), HOMA-IR ( p < 0.001) and with lower ISI-Matsuda ( p 0.005) and HDL-cholesterol ( p < 0.001). Higher degree of adipose tissue dysfunction associated with increased insulin resistance. No gender difference was found for visceral adiposity index, adipose tissue dysfunction severity, and cardiovascular risk scores. Patients with adulthood onset craniopharyngioma showed higher Framingham risk score ( p 0.004), atherosclerotic cardiovascular disease 10-year ( p < 0.001) and lifetime ( p 0.018) risk scores than those with childhood onset disease. Conclusions Visceral adiposity index is increased in one third of our patients with craniopharyngioma, even if metabolic syndrome does not occur. Increased visceral adiposity index and adipose tissue dysfunction severity correlate with insulin sensitivity parameters, do not correlate with Framingham or atherosclerotic cardiovascular disease risk scores, and are not influenced by gender and age of disease onset.
MoreTranslated text
Key words
Cardiometabolic risk,Cardiovascular risk,Craniopharyngioma,Hypopituitarism,Visceral adiposity index
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined