Amelogenin induces M2 macrophage polarisation via PGE2/cAMP signalling pathway.

Kensuke Yamamichi,Takao Fukuda,Terukazu Sanui,Kyosuke Toyoda,Urara Tanaka,Yuki Nakao,Karen Yotsumoto,Hiroaki Yamato,Takaharu Taketomi,Takeshi Uchiumi,Fusanori Nishimura

Archives of Oral Biology（2017）

引用 12|浏览16

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摘要

•Amelogenin regulates the expression of inflammatory response genes in macrophages.•Amelogenin can reprogram macrophages towards an anti-inflammatory M2 phenotype.•Amelogenin induced M2 macrophage polarization via PGE2/cAMP signalling pathway.

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关键词

Amelogenin,Enamel matrix derivative,Macrophage,Microarray,Prostaglandin E2

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