Nanoemulsion-Loaded Hydrogels for Topical Administration of Pentyl Gallate

The aim of this study is to describe the development of nanoemulsion-loaded hydrogels to deliver pentyl gallate (PG), a gallic acid n -alkyl ester, through the skin. PG is an antioxidant agent; however, it seems to be a promising agent for herpis labialis treatment. Aristoflex AVC ® and chitosan were used as gelling agents for nanoemulsion thickening. The developed formulations presented suitable PG content (94.4–100.3% w / w ), nanometric droplet sizes (162–297 nm), high zeta potentials, and a non-Newtonian pseudoplastic behavior. Both vehicles neither enhanced PG penetration nor delayed its release from the nanoemulsion. Formulations remained physically stable at 8°C during 3 months of storage.