Tracking age-correlated DNA methylation markers in the young

Ana Freire-Aradas,Christopher Phillips,Lorena Girón-Santamaría,Ana Mosquera-Miguel,Antonio Gómez-Tato,M. Ángeles Casares de Cal,Jose Álvarez-Dios,Maria Victoria Lareu

Forensic Science International: Genetics（2018）

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摘要

•Candidate age-correlated CpG sites explored in public datasets of 398 young subjects (3–17 yrs).•3 most correlated genes selected and tested in 209 new DNAs (2–18 yrs) + 7 previous adult-informative age markers.•CpGs in KCNAB3 have strongest correlation of methylation status with pre-adult age ranges.•Quantile regression prediction model extended with 6 most young-informative CpGs has ±0.94 yr median absolute error.

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关键词

DNA methylation,Children,Adolescents,Individual age,Illumina,EpiTYPER®,Age estimation

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