Human OATP1B1 (SLCO1B1) transports sulfated bile acids and bile salts with particular efficiency.

Beáta Tóth,Márton Jani,Erzsébet Beéry,Teresa Heslop,Mark Bayliss,Neil R Kitteringham,B Kevin Park,Richard J Weaver,Peter Krajcsi

Toxicology in Vitro（2018）

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摘要

Human OATP1B1 is highly expressed at the basolateral membrane of the hepatocyte. It plays an important role in the sodium-independent transport of bile acids and bile salts and contributes to the systemic clearance of many drugs.

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关键词

Bile acid,OATP1B1,SLCO1B1,Sulfated bile salts,Substrate specificity

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