The role of uric acid in the pathogenesis of diabetic retinopathy based on notch pathway.
Biochemical and Biophysical Research Communications(2018)
Abstract
Our study reported that high uric acid can promote the inflammation of the retina and increase the activity of Notch signaling pathway on the basis of high glucose. Hyperuricemia promotes the development of diabetic retinopathy by increasing the activity of Notch signaling pathway. Notch signaling pathway is a potential therapeutic target for diabetic retinopathy.
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Key words
Diabetic retinopathy,Uric acid,Notch signaling pathway,Inflammatory cytokines
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