Effects of Histone Methyltransferase Inhibitor Chaetocin on Histone H3K9 Methylation of Cultured Ovine Somatic Cells and Development of Preimplantation Cloned Embryos.
Reproductive Toxicology（2018）
Abstract
•Chaetocin down-regulates H3K9 di- and trimethylation levels in cultured ovine cells.•Chaetocin suppresses the expression of H3K9 methyltransferases.•Chaetocin-treated cells can be used as donor cells for somatic cell nuclear transfer.•Chaetocin impairs the development of embryos.
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Key words
Somatic cell nuclear transfer,Histone H3K9 methylation,Chaetocin,SUV39H,G9A,Sheep,Embryo
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