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Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy.

Chunhong Shen,Bijun Zhang,Zhirong Liu,Yelei Tang,Yinxi Zhang,Shan Wang,Yi Guo,Yao Ding,Shuang Wang,Meiping Ding

Seizure（2017）

Cited 25|Views24
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Abstract
•The effects of 4 SNPs on OXC level and response in patients with epilepsy were studied.•ABCB1 rs1045642 was related with normalized OXC concentration and responsiveness.•UGT2B7 rs7439366 polymorphism exhibited an association with OXC responsiveness.
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Key words
Oxcarbazepine,Pharmacogenetics,ABCB1,ABCC2,UGT2B7,HNF4α
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