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Gonococcal MtrE and its surface-expressed Loop 2 are immunogenic and elicit bactericidal antibodies.

Shuyi Wang,Juan Xue,Ping Lu,Chunshan Ni,Hao Cheng,Rui Han,Stijn van der Veen

Journal of Infection（2018）

Cited 23|Views12
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Abstract
•In silico analysis identified MtrE as a conserved surface-expressed vaccine antigen.•MtrE is essential for host survival and will not show sequence or phase variation.•MtrE and its Loop 2 are immunogenic and elicit bactericidal antibodies.
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Key words
Neisseria gonorrhoeae,Vaccine,MtrE,MtrCDE,Epitope display,Loop 2,IMX315,C4bp,SBA
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