Gonococcal MtrE and its surface-expressed Loop 2 are immunogenic and elicit bactericidal antibodies.
Journal of Infection(2018)
Abstract
•In silico analysis identified MtrE as a conserved surface-expressed vaccine antigen.•MtrE is essential for host survival and will not show sequence or phase variation.•MtrE and its Loop 2 are immunogenic and elicit bactericidal antibodies.
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Key words
Neisseria gonorrhoeae,Vaccine,MtrE,MtrCDE,Epitope display,Loop 2,IMX315,C4bp,SBA
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