Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma.

Atsushi Shiozaki,Shoichiro Hikami,Daisuke Ichikawa,Toshiyuki Kosuga,Hiroki Shimizu,Michihiro Kudou,Yuzo Yamazato,Toshiyuki Kobayashi,Katsutoshi Shoda,Tomohiro Arita,Hirotaka Konishi,Shuhei Komatsu,Takeshi Kubota,Hitoshi Fujiwara,Kazuma Okamoto,Mitsuo Kishimoto,Eiichi Konishi,Yoshinori Marunaka,Eigo Otsuji

Oncotarget（2018）

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摘要

In human ESCC cell lines, knockdown experiments were conducted using AE2 siRNA, and the effects on cellular movement and survival were analyzed. The gene expression profiles of cells were examined using a microarray analysis. An immunohistochemical analysis was performed on 61 primary tumor samples obtained from ESCC patients who underwent esophagectomy.

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关键词

AE2,MMPs,cellular physiology,esophageal squamous cell carcinoma,migration

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