Acetylcholinesterase And A Beta Aggregation Inhibition By Heterometallic Ruthenium(Ii)-Platinum(Ii) Polypyridyl Complexes

Two heteronuclear ruthenium(II)-platinum(II) complexes [Ru-(bpy)(2)(BPIMBp)PtCl2](2)+ (3) and [Ru(phen)(2)(BPIMBp)PtCl2](2+) (4), where bpy = 2,2'-bipyridine, phen = 1,10-phenanthroline, and BPIMBp = 1,4'-bis[(2-pyridin-2-yl)-1H-imidazol-1-ylmethyl]-1,1'-biphenyl, have been designed and synthesized from their mononuclear precursors [Ru(bpy)(2)(BPIMBp)](2+) (1) and [Ru-(phen)(2)(BPIMBp)](2+) (2) as multitarget molecules for Alzheimer's disease (AD). The inclusion of the cis-PtCl2 moiety facilitates the covalent interaction of Ru(II) polypyridyl complexes with amyloid beta (A beta) peptide. These multifunctional complexes act as inhibitors of acetylcholinesterase (AChE), A beta aggregation, and Cu-induced oxidative stress and protect neuronal cells against A beta-toxicity. The study highlights the design of metal based anti-Alzheimer's disease (AD) systems.