Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood

Helene Johansson,Lisa-Mari Mörk,Meng Li,Anita L. Sandblom,Ingemar Björkhem,Jonas Höijer,Bo-Göran Ericzon,Carl Jorns,Stefan Gilg,Ernesto Sparrelid,Bengt Isaksson,Greg Nowak,Ewa Ellis

Journal of Clinical and Experimental Hepatology（2018）

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摘要

Our results confirm that bile acids drive the postprandial increase of circulating FGF19 but a hepatic clearance of FGF19 is unlikely. We conclude that systemic concentrations of FGF19 reflect portal concentrations of FGF19.

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关键词

CA,CDCA,CYP7A1,DCA,FGF19,FXR,LCA,SHP,UDCA

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