Galectin-7 promotes proliferation and Th1/2 cells polarization toward Th1 in activated CD4+ T cells by inhibiting The TGFβ/Smad3 pathway.
Molecular Immunology（2018）
Abstract
•Galectin-7 enhanced the proliferation of activated CD4+ T cells in a dose-dependent manner.•Galectin-7 treatment upregulated the ratio of Th1 cells in activated CD4+ T cells.•The mitogenic effects of Galectin-7 are associated with a proinflammatory microenvironment.•Galectin-7 promotes proliferation and Th1/2 cells polarization toward Th1 by inhibiting the TGFβ/Smad3 pathway.
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Key words
Galectin-7,CD4+ T cells,Proliferation,Th1/2 cells balance,TGFβ/Smad3 pathway
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