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Essential function of VCP/p97 in infection cycle of the nucleopolyhedrovirus AcMNPV in Spodoptera frugiperda Sf9 cells.

Yulia V Lyupina,Pavel A Erokhov,Oksana I Kravchuk,Alexander D Finoshin,Svetlana B Abaturova,Olga V Orlova,Svetlana N Beljelarskaya,Margarita V Kostyuchenko,Victor S Mikhailov

Virus Research（2018）

Cited 9|Views29
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Abstract
•VCP/p97 ATPase is an abundant protein in Sf9 cells that forms a stable homohexamer.•Inhibition of VCP/p97 by NMS-873 blocks infection cycle of baculovirus AcMNPV.•Function of VCP/p97 in AcMNPV infection relates to ubiquitin-proteasome pathway.•Inhibitory effect of NMS-873 on budded virions production declines in infection cycle.
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Key words
VCP/p97,TER94,Baculovirus,AcMNPV,Insects,Spodoptera frugiperda
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