Leishmania infantum exerts immunomodulation in canine Kupffer cells reverted by meglumine antimoniate.

A Rodrigues,D Santos-Mateus,G Alexandre-Pires,A Valério-Bolas,M Rafael-Fernandes,M A Pereira,D Ligeiro,J de Jesus, R Alves-Azevedo, S Lopes-Ventura,M Santos,A M Tomás,I Pereira da Fonseca,G Santos-Gomes

Comparative Immunology, Microbiology and Infectious Diseases（2017）

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摘要

•Canine Kupffer cells (KC) internalize both promastigotes and amastigotes of Leishmania infantum.•Parasite internalization does not direct activation of KC innate immune receptors.•Infected-KC are anergic, presenting no distinctive cytokine gene expression.•Meglumine antimoniate reverts KC anergy, increasing gene expression of Toll-like receptors 2 and 4.•After treatment, activated KC generate pro-inflammatory and regulatory cytokines.

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关键词

Canine Kupffer cells,Cytokines,Innate immune receptors,Innate immunity,Leishmania infantum

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