[The Effects of NF-kappaB Signalling on the TNF-α induced Ratios of MMPs to TIMPs in Chondrocytes].

Lin-Yi Cai,Xiang-Li Kong,Qiang Xie,Jing Xie

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition（2016）

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摘要

TNF-α-induced high ratios of MMPs/TIMPs could partiallyexplain over-degradation of cartilage extracellular matrix in osteoarthritis (OA). Blockage of NF-κB with bay11-7082 might provide a possible therapeutic strategy for the OA deterioration.

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关键词

Chondrocyte,MMPs,NF-κB,TIMPs,TNF-α

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