LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis.

Charles Thomas,Antoine Jalil,Charlène Magnani,Minako Ishibashi,Ronan Queré,Thibaut Bourgeois,Victoria Bergas,Louise Ménégaut,Danish Patoli,Naig Le Guern,Jérôme Labbé,Thomas Gautier,Jean Paul Pais de Barros,Laurent Lagrost,David Masson

Atherosclerosis（2018）

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摘要

•LPCAT3 controls arachidonic acid incorporation into glycerophospholipids in macrophages.•Alteration of arachidonic acid availability inhibits LXR pathways such as cholesterol efflux in Lpcat3−/− macrophages.•LPCAT3 deficiency in hematopoieic cells promotes atherosclerosis development in recipient Ldlr−/− mice.

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关键词

Cholesterol efflux,Phospholipid,Arachidonic acid,Macrophage,Atherosclerosis

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