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Interleukin 17A exacerbates ER-stress-mediated inflammation of macrophages following ICH.

Zhao Yang,Qingjun Liu,Hui Shi,Xuheng Jiang,Song Wang,Yuanlan Lu,Ji Zhang,Xiaofei Huang,Anyong Yu

Molecular Immunology（2018）

Cited 16|Views6
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Abstract
•IL-17A induced ER stress in macrophages and promoted inflammation in vitro.•ERK 1/2 and p38 MAPK pathways contributed to IL-17A induced ER stress of macrophage.•ER stress inhibition significantly attenuated brain water content and brain injury of ICH mice.•IL-17A induced ER stress represented a novel clue in ICH.
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Key words
IL-17A,ER stress,Inflammation,Macrophages,ICH
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