Molecular characterization of the Silencing complex SIR in Candida glabrata hyperadherent clinical isolates.

Osney Leiva-Peláez,Guadalupe Gutiérrez-Escobedo,Eunice López-Fuentes, José Cruz-Mora,Alejandro De Las Peñas,Irene Castaño

Fungal Genetics and Biology（2018）

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摘要

•C. glabrata clinical isolates can be non-adherent or highly adherent to epithelial cells.•The SIR complex is required for subtelomeric silencing of EPA genes.•Sir3 and Sir4 from hyperadherent isolates contain multiple polymorphisms.•The most adherent isolate MC2, contains a non-functional, recessive Sir3 allele.

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关键词

Candida glabrata,Hyperadherence,Clinical isolates,SIR complex,Polymorphisms,SIR3,SIR4

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