One bis-indole alkaloid-voacamine from Voacanga africana Stapf: biological activity evaluation of PTP1B in vitro utilizing enzymology method based on SPRi expriment

Yan-Qiu Wang,Hong-Xiang Li,Xiao-Chun Liu,Jin-Shuang Zhao, Rong-Qiang Liu,Wen-Ying Huai,Wei-Jun Ding,Tian-E Zhang,Yun Deng

Natural Product Research（2019）

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摘要

One known bis-indole alkaloid-voacamine was isolated from Voacanga africana Stapf and Surface Plasmon Resonance imaging (SPRi) exprement showed that this alkaloid could be combine with Protein Tyrosine Phosphatase1B (PTP1B). Then the PTP1B activity inhibition experiment display that the compound showed an outstanding promoting activity to PTP1B.

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关键词

Bis-indole alkaloids,PTP1B,SPRi,Voacanga africana Stapf,voacamine

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