Chitosan encapsulation modulates the effect of trans-cinnamaldehyde on AHL-regulated quorum sensing activity.

•Trans-cinnamaldehyde, vanillin and caffeine were efficiently loaded into nanosystems.•Trans-cinnamaldehyde has higher encapsulation efficiency than vanillin and caffeine.•Chitosan-based nanocapsules could deliver the drug target on the bacterial surface.•The bioactivity of trans-cinnamaldehyde was improved upon their nanocapsulation.