Aberrant Peripheral Immune Function in a Good Syndrome Patient.
JOURNAL OF IMMUNOLOGY RESEARCH(2018)
Abstract
Good's syndrome (GS) is often accompanied by recurrent respiratory infections and chronic diarrhea. The main purpose was to evaluate the peripheral immune status of a GS patient after thymoma resection. Twenty healthy volunteers were recruited as healthy controls (HCs). Flow cytometry was applied to determine the proportions of circuiting CD4(+) T cells, CD8(+) T cells, gamma delta T cells, and regulatory T (Treg) cells in our GS patient. We also examined the proliferation capability of ex vivo CD4(+) T cells and detected the levels of cytokines interferon- (IFN-) gamma and interleukin-17A secreted by ex vivo immune cells from this GS patient. Compared with healthy control subjects, this GS patient had fewer B cells, an inverted ratio of CD4(+)/CD8(+) cells, and more Treg cells in his peripheral blood. Additionally, the patient's V delta 2 T cell levels were significantly decreased despite having a normal percentage of gamma delta T cells. Ex vivo peripheral CD4(+) T cells from the patient showed insufficient proliferation and division potential as well as excessive expression of PD-1. Moreover, IFN-gamma was predominantly derived from CD8(+) T cells in this GS patient, rather than from CD4(+) T cells and gamma delta T cells. This GS patient had impaired T and B cell immunological alternations and cytokine disruptions after thymectomy. Detailed research should focus on therapies that can adjust the immune status in such patients for a better outcome.
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Key words
immune function,syndrome
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