68Ga-PSMA PET/MR-Positive, Histopathology-Proven Prostate Cancer in a Patient With Negative Multiparametric Prostate MRI.

Multiparametric MRI incorporating T2-weighted, diffusion-weighted, and dynamic contrast material-enhanced sequences is currently used for detection and localization of clinically important prostate cancer (PCa). The Ga-68-labeled PET tracer targeting the prostate-specific membrane antigen (PSMA, Ga-68-PSMA-11) is a promising diagnostic approach for staging and restating PCa. Recent studies suggest that Ga-68-PSMA could also be used for primary PCa detection and localization. We report a case of a Ga-68-PSMA PET/MR-positive lesion of the peripheral zone in a 73-year-old man with a negative preceding multiparametric MRI. Radical prostatectomy and subsequent histopathologic examination confirmed a Gleason 4 + 4 PCa.