Sustained therapeutic efficacy of budesonide-loaded chitosan swellable microparticles after lung delivery: Influence of in vitro release, treatment interval and dose
Journal of Controlled Release(2018)
Abstract
Sustained drug delivery to the respiratory tract is highly desirable for local treatment of chronic lung diseases. In this context, a correlation of in vitro drug release with in vivo efficacy data is essential to accelerate the application of sustained drug delivery system for inhalation into the clinical setting.
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Key words
Chitosan,Lung,Sustained drug delivery,Swellable microparticles,Therapeutic efficacy,Treatment interval,Eosinophils,IL-4,IL-5
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