α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis.

Tianhang Wang,Jiling Cheng,Shuyu Wang, Xudong Wang,Hongquan Jiang,Yueqing Yang,Ying Wang,Chunting Zhang,Weiwei Liang,Honglin Feng

Brain Research Bulletin（2018）

Cited 36|Views16

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Abstract

•LA improves motor activity and lifespan in a mutant hSOD1G85R fly model of ALS.•LA increases the resistant to ROS damage in NSC34 cells of mutant hSOD1G93A.•LA upregulates antioxidant enzymes through ERK-Akt signaling pathway in ALS models.

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Key words

ALS,CAT,CNS,CCK8,DHE,DMSO,DMEM,ERK,FBS,fALS,Gpx,GR,Grx,HO-1,LA,MDA,MAPK,MNs,MEK,NQO1,PBS,PI3K,RNS,ROS,SEM,SOD1,WT

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