Optical Biometry Derived Axial Length Measurements Following Intravitreal Anti-Vascular Endothelial Growth Factor Treatment for Macular Edema.

Purpose: To evaluate axial length (AL) alterations in patients with macular disease over the course of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment. Methods: In this prospective, comparative study, 33 patients with macular edema underwent unilaterally intravitreal anti-VEGF therapy and were followed for two months; the contralateral eyes were considered as controls. Central retinal thickness (CRT) was measured with spectral-domain optical coherence tomography and AL with an IOL-Master optical biometer. Results: CRT of the treated eyes decreased by 35.33 +/- 65.59 mu m (range, -222.00-67 mu m), while AL increased by 0.008 +/- 0.062 mm (range, -0.11-0.18 mm). CRT of the control group decreased by 9.82 +/- 65.40 mu m (range, -203-182 mu m), and AL increased by 0.011 +/- 0.129 mm (range, -0.20-0.67 mm). No significant correlation was detected between CRT and AL parameters (rhos=0.026, P=0.882). Conclusions: Anti-VEGF administration has no significant impact on optical biometry-derived AL measurements.