Macrophages Contribute to the Pathogenesis of Sclerosing Cholangitis in Mice.

•Peribiliary macrophages are increased in PSC and animal models of PSC.•Both M1-like and M2-like peribiliary macrophages are increased.•Genetic and pharmacologic CCR2 inhibition restrains monocyte recruitment.•CCR2 inhibition reduces fibrosis and cholestasis in animal models of PSC.•These studies support the use of CCR2 inhibitors in human PSC.