N-stearoyltyrosine protects primary cortical neurons against oxygen-glucose deprivation-induced apoptosis through inhibiting anandamide inactivation system.

Heng-Jing Cui,Sha Liu,Rui Yang,Guo-Hui Fu,Yang Lu

Neuroscience Research（2017）

Cited 3|Views4

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Abstract

•NST protects cortical neurons against OGD-induced injury.•NST protects neurons against OGD-induced injury via anti-apoptosis pathway.•NST protects neurons against OGD-induced injury via MAPK/ERK signaling pathway.•NST protects neurons against OGD-induced injury by blocking AMT.•NST protects neurons against OGD-induced injury by inhibiting FAAH.

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Key words

Anandamide (AEA),Anandamide inactivation system,N-stearoylthrosine (NST),Oxygen-glucose deprivation (OGD),Endocannabinoid system (ECS)

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