[Desmocollin-1 significant correlated with the tumorigenesis and prognosis of HNSCC].

Objective:To explore the correlation between the expression of desmocollin1and the tumorigenesis and prognosis of HNSCC.Method:Five datasets of HNSCC from the GEO were analyzed. A tumor tissue microassay was chosen for further test. The expression of DSC1 of TMA was detected by immunohistochemical staining. Result:The expression of DSC1 was significantly increased in HNSCC. Meanwhile, the expression of DSC1 was much higher in poor-differentiated tumor than the welldifferentiated tumor in HNSCC. What's more, the HNSCC patients with lower expression of DSC1 had better outcomes. Conclusion:The results were according with the results of statistical analysis with the bioinformatics data from GEO, indicating that DSC1 significant correlated with the tumorigenesis and prognosis of HNSCC.