Concise Total Syntheses of Crinipellins Enabled by Co-Mediated and Pd-Catalyzed Intramolecular Pauson-Khand Reactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(2018)
Abstract
Efficient total syntheses of the naturally occurring, potent antibiotic compounds (-)-crinipellinA and (-)-crinipellinB are described. The key advanced intermediate, a fully functionalized tetraquinane core, was constructed by a novel thiourea/palladium-catalyzed Pauson-Khand reaction. This intermediate can serve as a common intermediate for the collective total synthesis of other members of the crinipellin family.
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Key words
asymmetric synthesis,natural products,palladium,Pauson-Khand reaction,quaternary carbon centers
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