Measuring drug absorption improves interpretation of behavioral responses in a larval zebrafish locomotor assay for predicting seizure liability.
Journal of Pharmacological and Toxicological Methods(2017)
摘要
Disproportionately low exposures in larvae giving false negative results demonstrate that drug exposure analysis can help interpret results. Due to the rigorous testing commonly performed in preclinical toxicology, predicting convulsions in those studies may be more difficult than predicting effects from marketed drugs.
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关键词
4-Aminopyridine (PubChem CID: 1727),Bicuculline (PubChem CID: 10,237),Gabazine (PubChem CID: 107,896),Kainic acid (PubChem CID: 10,255),Methotrexate (PubChem CID: 126,941),Pentetrazol (PubChem CID: 5917),Picrotoxin (PubChem CID: 31,304),Quinolinic acid (PubChem CID: 1066),Strychnine (PubChem CID: 441,071),Baclofen (PubChem CID: 2284)
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