Raptor/mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease.
Molecular Metabolism（2016）
Abstract
•A new model of Raptor (mTORC1) loss in adipose tissue is described.•Young fat Raptor KO mice have normal WAT mass.•Fat Raptor KO mice progressively develop lipodystrophy and metabolic disease.•Fat Raptor KO mice resist obesity but develop severe hepatomegaly.
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Key words
mTORC1,Raptor,Rapamycin,Lipodystrophy,Obesity,White Adipose Tissue (WAT)
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