IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk.

•IRX3 expression was positively correlated with the browning markers in both mice and humans.•IRX3 deficiency repressed the browning program in human and mouse cell models by regulating UCP1 transcriptional activity.•Rare variants of IRX3 were associated with human obesity.