Early NT-proBNP levels as a screening tool for the detection of hemodynamically significant patent ductus arteriosus during the first week of life in very low birth weight infants
JOURNAL OF PERINATOLOGY(2018)
摘要
Objective To assess whether early NT-ProBNP can identify the need for echocardiographic assessment of hemodynamically significant patent ductus arteriosus (HsPDA) in preterm infants. Study design Prospective observational study of infants with a gestational age ≤32 weeks. Echocardiographic assessment and NT-proBNP measurement were performed at 48–96 h. ROC curves were generated to assess optimal cutoffs to detect HsPDA and predict the need for treatment. Results Eighty-five patients were included. HsPDA was present in 28 infants (37.6%), and 22 (25.8%) received treatment. The optimal NT-proBNP cutoff for the detection of HsPDA was 5099 pg/mL (sensitivity 94%, specificity 82%, area under the curve 0.941, P < 0.001). Only 1 child with NT-proBNP levels <5099 pg/mL was ultimately treated for PDA. NT-proBNP screening could have avoided 45 of 85 routine echocardiograms (53%). Conclusion NT-proBNP screening at 48–96 h of life may identify preterm infants at low risk for HsPDA, improving PDA management.
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关键词
Circulation,Predictive markers,Medicine/Public Health,general,Pediatrics,Pediatric Surgery
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