Fas/FasL interaction mediates imbalanced cytokine/cytotoxicity responses of iNKT cells against Jurkat cells.

•iNKT cells exhibited imbalanced cytokine/cytotoxicity responses against Jurkat cells.•The imbalanced iNKT cell responses were CD1d dependent and relied mostly on Fas/FasL interaction.•Elevated CD1d levels and defects of iNKT cells were found in T-cell lymphoma patients.•Exogenous IL-2 helped to overcome the defects of iNKT cells from T lymphoma patients.