A viral-vectored RSV vaccine induces long-lived humoral immunity in cotton rats.

Jessica L Grieves,Zhiwei Yin,Adolfo Garcia-Sastre,Ignacio Mena,Mark E Peeples,Heidi P Risman,Hannah Federman,Marvin J Sandoval,Russell K Durbin,Joan E Durbin

Vaccine（2018）

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摘要

•A NDV-vectored RSV vaccine protects cotton rats from RSV challenge.•This vaccine induces long-lived neutralizing antibody.•This vaccine candidate can be used to immunize RSV immune animals.

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关键词

Respiratory syncytial virus,Cotton rat,Virus-vectored,Inflammatory response,B cell memory,Upper airway

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