Inhibition of notch signaling pathway temporally postpones the cartilage degradation progress of temporomandibular joint arthritis in mice.

In our study, the results of the current study indicated the following:•In the TMJOA mouse model, Notch signaling pathway was rapidly increased, and was consistently active during the development of cartilage degradation during TMJOA.•After blocking Notch signaling by DAPT, the progression of cartilage damage occurred later than in the control group.•The cartilage degradation progress was postponed but not inhibited by DAPT treatment, suggesting that blocking Notch signaling pathway can partially delay the progress of cartilage degradation in TMJOA mice.