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New insights into the inflamed tumor immune microenvironment of gastric cancer with lymphoid stroma: from morphology and digital analysis to gene expression

Irene Gullo,Patrícia Oliveira,Maria Athelogou,Gilza Gonçalves,Marta L. Pinto,Joana Carvalho, Ana Valente,Hugo Pinheiro,Sara Andrade,Gabriela M. Almeida,Ralf Huss,Kakoli Das,Patrick Tan,José C. Machado,Carla Oliveira,Fátima Carneiro

Gastric Cancer（2019）

Cited 43|Views57
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Abstract
Gastric cancer with lymphoid stroma (GCLS) is characterized by prominent stromal infiltration of T-lymphocytes. The aim of this study was to investigate GCLS biology through analysis of clinicopathological features, EBV infection, microsatellite instability (MSI), immune gene-expression profiling and PD-L1 status in neoplastic cells and tumor immune microenvironment.
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Key words
Gastric cancer,Epstein–Barr virus (EBV),Microsatellite instability (MSI),Gene expression profiling,PD-L1
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