Hordenine protects against hyperglycemia-associated renal complications in streptozotocin-induced diabetic mice.

•Combination of HOR and insulin reduce blood glucose level in diabetic mice.•HOR and insulin function synergistically to ameliorate renal injury in diabetic mice.•HOR and insulin play synergistic roles to inhibit inflammation and fibrosis in kidney.•HOR and insulin function synergistically to enhance antioxidant defense in kidney.•HOR functions synergistically with insulin and prevents diabetic nephropathy.