The role of the vasopressin system and dopamine D1 receptors in the effects of social housing condition on morphine reward.

M L Shawn Bates,Rebeca S Hofford,Michael A Emery,Paul J Wellman,Shoshana Eitan

Drug and Alcohol Dependence（2018）

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摘要

•Housing with drug-naïve animals protects against the development of opioid reward.•Morphine induced an increase in striatal expression levels of D1DR and AVP.•Housing with drug-naïve animals diminished these effects on striatal expression.•Inhibiting AVP-V1b receptors reduced the acquisition of morphine CPP.•Protective effects of housing on the development of opioid reward is mediated by AVP.

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Social environment,Opioid abuse,Morphine conditioned place-preference,Adolescents

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