Specific Polysaccharide Antibody Deficiency Revealed by Severe Bacterial Infections in Adulthood: A Report on 11 Cases.

Benjamin Lopez,Anne Boucher,Mathilde Bahuaud,Geoffrey Mortuaire,Hugues Melliez, David Launay,Louis Terriou,Lidwine Wemeau-Stervinou, Benoît Wallaert,Karine Faure,Frédéric Wallet, Eric Hachulla, Pierre-Yves Hatron,Sylvain Dubucquoi,Frédéric Batteux,Myriam Labalette,Guillaume Lefèvre

CLINICAL INFECTIOUS DISEASES（2017）

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摘要

We report on 11 cases of specific polysaccharide antibody deficiency (SPAD) revealed in adulthood by severe infections with encapsulated bacteria. Given that immunoglobulin replacement therapy can effectively prevent the recurrence of bacterial infections in this context, SPAD should be considered once other antibody deficiencies have been ruled out.

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关键词

specific polysaccharide antibody deficiency,primary immunodeficiency,Streptococcus pneumonia,Group A Streptococcus,Haemophilus influenzae type b

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